Data de publicação
Janeiro de 2024
Periódico
Public Health
Resumo
Objetives – Since the beginning of the COVID-19 pandemic, changes in the circulation of respiratory viruses have been observed after measures to control the spread of SARS-CoV-2 were implemented. In this sense, we aimed to understand the circulation of the respiratory virus and its impact in a controlled healthy population of healthcare professional (HCP) volunteers in phase III of the clinical trial of the ChadOx nCoV1 conducted in São Paulo, Brazil.
Study design – This was a nested observational cohort study within a clinical trial.
Methods – We performed RT-qPCR to detect SARS-CoV-2, influenza virus A and B (IVA and IVB), respiratory syncytial virus (RSV), human rhinovirus (HRV), human metapneumovirus (hMPV), human coronaviruses (hCoVs: HKU-1, NL63, OC43, and 229-E), parainfluenza virus (PiV) I–IV, and q-PCR for adenovirus in nasopharyngeal and oropharyngeal samples obtained from HCP enrolled in the clinical trial to assess respiratory viruses infection among vaccinated and non-vaccinated.
Results – From July 2020 to January 2022, 876 samples were included from 737 volunteers (median age: 33 years, 62.9% female). New episodes were registered for 119 individuals. We observed an overall positivity of 37.7% for SARS-CoV-2 and 16.4% for other respiratory viruses; HRV was the second most detected virus (8%), followed by RSV (2.4%). Fully vaccinated individuals accounted for 53.3% of collected samples, and 52.9% presented at least one respiratory virus infection, with SARS-CoV-2 being the most predominant etiologic agent (62.3%). Influenza and hMPV were not detected among the tested samples. Among the subjects that presented more than one episode, SARS-CoV-2 and HRV infections were related to direct contact with patients (P < 0.002).
Conclusions – Data show high infection rates among HCPs even under mask policies and contact precautions, highlighting the need for improvement in infection control measures in this population regardless of the vaccination program.
DOI/link
https://doi.org/10.1590/S1679-49742021000100017
Autoria
Vínculo institucional
Lattes
Orcid
Gabriela Rodrigues Barbosa
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Felipe Alberto-Lei
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Ana Paula Cunha Chaves
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Joseane Mayara Almeida Carvalho
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Danielle Dias Conte
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Luiz Vinicius Leão Moreira
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Luciano Kleber de Souza Luna
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Ana Helena Sitta Perosa
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil
Nancy Cristina Junqueira Bellei
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brazil